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Uremia is the condition of having high levels of urea in the blood. Urea is one of the primary components of urine.It can be defined as an excess in the blood of amino acid and protein metabolism end products, such as urea and creatinine, which would normally be excreted in the urine.
Unless high blood levels of uric acid are determined in a clinical laboratory, hyperuricemia may not cause noticeable symptoms in most people. [5] Development of gout – which is a painful, short-term disorder – is the most common consequence of hyperuricemia, which causes deposition of uric acid crystals usually in joints of the extremities, but may also induce formation of kidney stones ...
When the body is unable to eliminate urea, it can cause a serious medical condition called uremia, which is a high level of urea in blood. Symptoms of uremia include nausea, vomiting, fatigue, anorexia, weight loss, and change in mental status. If left untreated, uremia can lead to seizure, coma, cardiac arrest, and death. [28] [29]
In medicine, the urea-to-creatinine ratio (UCR [1]), known in the United States as BUN-to-creatinine ratio, is the ratio of the blood levels of urea (mmol/L) and creatinine (Cr) (μmol/L). BUN only reflects the nitrogen content of urea (MW 28) and urea measurement reflects the whole of the molecule (MW 60), urea is just over twice BUN (60/28 ...
It may initially cause no symptoms. [28] In later stages, it can lead to difficulty urinating, blood in the urine or pain in the pelvis, back, or when urinating. [31] A disease known as benign prostatic hyperplasia may produce similar symptoms. [28] Other late symptoms may include feeling tired due to low levels of red blood cells. [28]
Due to its high systemic concentration, urea is excreted in eccrine sweat at high concentrations and crystallizes on skin as the sweat evaporates ("uremic frost"). Potassium accumulates in the blood (hyperkalemia with a range of symptoms including malaise and potentially fatal cardiac arrhythmias).
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Symptoms may include leg swelling, feeling tired, vomiting, loss of appetite, and confusion. [2] Complications of acute and chronic failure include uremia, hyperkalemia, and volume overload. [3] Complications of chronic failure also include heart disease, high blood pressure, and anaemia. [4] [5]