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The thiazolidinediones / θ aɪ. ə ˌ z oʊ l ɪ d iː n ˈ d aɪ. oʊ n /, abbreviated as TZD, also known as glitazones after the prototypical drug ciglitazone, [1] are a class of heterocyclic compounds consisting of a five-membered C 3 NS ring.
Useful thiazolidines include the drug pioglitazone, the antibiotic penicillin, and N-Methyl-2-thiazolidinethione, an accelerator for the vulcanization of chloroprene rubbers. [4] Thiazolidines functionalized with carbonyls at the 2 and 4 positions, the thiazolidinediones, are drugs used in the treatment of diabetes mellitus type 2.
PPARγ (gamma) is the main target of the drug class of thiazolidinediones (TZDs), used in diabetes mellitus and other diseases that feature insulin resistance. It is also mildly activated by certain NSAIDs (such as ibuprofen) and indoles, as well as from a number of natural compounds. Known inhibitors include the experimental agent GW-9662.
Troglitazone is an antidiabetic and anti-inflammatory drug, and a member of the drug class of the thiazolidinediones. It was prescribed for people with diabetes mellitus type 2. [1] It was patented in 1983 and approved for medical use in 1997. [2] It was subsequently withdrawn.
Rosiglitazone is a member of the thiazolidinedione class of drugs. Thiazolidinediones act as insulin sensitizers. They reduce glucose, fatty acid, and insulin blood concentrations. They work by binding to the peroxisome proliferator-activated receptors (PPARs). PPARs are transcription factors that reside in the nucleus and become activated by ...
Pages in category "Thiazolidinediones" The following 13 pages are in this category, out of 13 total. This list may not reflect recent changes. ...
You've heard it a million times: Eat fewer calories, lose weight. But what if you're in a calorie deficit—consuming fewer calories than you're burning—and still not losing?
Lobeglitazone (trade name Duvie, Chong Kun Dang) is an antidiabetic drug in the thiazolidinedione class of drugs. As an agonist for both PPARα and PPARγ , it works as an insulin sensitizer by binding to the PPAR receptors in fat cells and making the cells more responsive to insulin.