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  2. Thiazolidinedione - Wikipedia

    en.wikipedia.org/wiki/Thiazolidinedione

    Thiazolidinedione ligand dependent transactivation is responsible for the majority of anti-diabetic effects. The activated PPAR/RXR heterodimer binds to peroxisome proliferator hormone response elements upstream of target genes in complex with a number of coactivators such as nuclear receptor coactivator 1 and CREB binding protein, this causes upregulation of genes (for a full list see PPARγ):

  3. PPAR agonist - Wikipedia

    en.wikipedia.org/wiki/PPAR_agonist

    PPARγ (gamma) is the main target of the drug class of thiazolidinediones (TZDs), used in diabetes mellitus and other diseases that feature insulin resistance. It is also mildly activated by certain NSAIDs (such as ibuprofen) and indoles, as well as from a number of natural compounds. Known inhibitors include the experimental agent GW-9662.

  4. Pioglitazone - Wikipedia

    en.wikipedia.org/wiki/Pioglitazone

    Pioglitazone is used to lower blood glucose levels in type 2 diabetes either alone or in combination with sulfonylurea, metformin, or insulin. [1] The effects of pioglitazone have been compared in a Cochrane systematic review to that of other blood sugar lowering-medicine, including metformin, acarbose, and repaglinide, as well as with appropriate diet and exercise, not showing any benefit in ...

  5. Troglitazone - Wikipedia

    en.wikipedia.org/wiki/Troglitazone

    Troglitazone is an antidiabetic and anti-inflammatory drug, and a member of the drug class of the thiazolidinediones. It was prescribed for people with diabetes mellitus type 2. [1] It was patented in 1983 and approved for medical use in 1997. [2] It was subsequently withdrawn.

  6. Rosiglitazone - Wikipedia

    en.wikipedia.org/wiki/Rosiglitazone

    Thiazolidinediones bind to PPARγ. PPARs are expressed in fat cells, cells of the liver, muscle, heart, and inner wall (endothelium) and smooth muscle of blood vessels. PPARγ is expressed mainly in fat tissue, where it regulates genes involved in fat cell (adipocyte) differentiation, fatty acid uptake and storage, and glucose uptake.

  7. US FDA approves Ionis Pharma's genetic disorder drug - AOL

    www.aol.com/news/us-fda-approves-ionis-pharmas...

    (Reuters) -The U.S. Food and Drug Administration has approved Ionis Pharmaceuticals' drug to treat a rare genetic disorder, making it the company's first wholly-owned drug, the health regulator's ...

  8. Ciglitazone - Wikipedia

    en.wikipedia.org/wiki/Ciglitazone

    Ciglitazone is a thiazolidinedione.Developed by Takeda Pharmaceuticals in the early 1980s, it is considered the prototypical compound for the thiazolidinedione class. [1] [2] [3] [4]

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