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Fatty-acid metabolism disorders result when both parents of the diagnosed subject are carriers of a defective gene. This is known as an autosomal recessive disorder. Two parts of a recessive gene are required to activate the disease. If only one part of the gene is present then the individual is only a carrier and shows no symptoms of the disease.
Hormonal disorder due to the body's inability to properly metabolize fat; Increase in fat cells ; Enzymatic defect or a change in the surface of the cells that could prevent the breakdown of fat; Poor lymphatic drainage; Defective regulation of mitochondria in brown fat. Brown fat is responsible for causing heat in times of stress or cold.
Lipodystrophy syndromes are a group of genetic or acquired disorders in which the body is unable to produce and maintain healthy fat tissue. [ 1 ] [ 2 ] The medical condition is characterized by abnormal or degenerative conditions of the body's adipose tissue .
A lipid storage disorder (or lipidosis) is any one of a group of inherited metabolic disorders in which harmful amounts of fats or lipids accumulate in some body cells and tissues. [1] People with these disorders either do not produce enough of one of the enzymes needed to metabolize and break down lipids or, they produce enzymes that do not ...
Example of an unsaturated fat triglyceride. Left part: glycerol, right part from top to bottom: palmitic acid, oleic acid, alpha-linolenic acid. Chemical formula: C 55 H 98 O 6. Fatty acids, stored as triglycerides in an organism, are a concentrated source of energy because they contain little oxygen and are anhydrous.
Ketone bodies are water-soluble molecules or compounds that contain the ketone groups produced from fatty acids by the liver (ketogenesis). [1] [2] Ketone bodies are readily transported into tissues outside the liver, where they are converted into acetyl-CoA (acetyl-Coenzyme A) – which then enters the citric acid cycle (Krebs cycle) and is oxidized for energy.
Lipid metabolism is often considered the digestion and absorption process of dietary fat; however, there are two sources of fats that organisms can use to obtain energy: from consumed dietary fats and from stored fat. [5] Vertebrates (including humans) use both sources of fat to produce energy for organs such as the heart to function. [6]
It has been suggested that a low-carb, high fat ketogenic diet can be used to help treat epilepsy in children. [6] Additionally, ketone bodies can be anti-inflammatory. [19] Some kinds of cancer cells are unable to use ketone bodies, as they do not have the necessary enzymes to engage in ketolysis.