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Dexamethasone is a fluorinated glucocorticoid medication [10] used to treat rheumatic problems, a number of skin diseases, severe allergies, asthma, chronic obstructive pulmonary disease (COPD), croup, brain swelling, eye pain following eye surgery, superior vena cava syndrome (a complication of some forms of cancer), [11] and along with antibiotics in tuberculosis. [10]
High-altitude cerebral edema (HACE) is a medical condition in which the brain swells with fluid because of the physiological effects of traveling to a high altitude. It generally appears in patients who have acute mountain sickness and involves disorientation, lethargy, and nausea among other symptoms.
In general, cytotoxic edema is linked to cell death in the brain through excessive cellular swelling. [1] During cerebral ischemia for example, the blood–brain barrier remains intact but decreased blood flow and glucose supply leads to a disruption in cellular metabolism and creation of energy sources, such as adenosine triphosphate (ATP). [1]
The excessive pressure damages the endothelial layer and the blood–brain barrier, leading to swelling (edema). The predilection toward the posterior brain may be explained by the reduced density of sympathetic innervation in the posterior circulation compared to the anterior circulation (thus a reduced adaptive capacity to fluctuations or ...
Brain injury (BI) is the ... Initially, there may be symptoms such as swelling, pain, ... In the case of brain damage from traumatic brain injury, dexamethasone and ...
Synthetic pharmaceutical drugs with corticosteroid-like effects are used in a variety of conditions, ranging from hematological neoplasms [3] to brain tumors or skin diseases. Dexamethasone and its derivatives are almost pure glucocorticoids, while prednisone and its derivatives have some mineralocorticoid action in addition to the ...
Meet the experts: Shannel Kassis Elhelou, PsyD, is a geropsychology and neuropsychology fellow at the Pacific Neuroscience Institute’s Brain Wellness and Lifestyle Programs at Providence Saint ...
Cerebral edema (swelling of the brain) Headache that does not respond to analgesics Unsteady gait Gradual loss of consciousness Increased nausea and vomiting Retinal hemorrhage. The most serious symptoms of altitude sickness arise from edema (fluid accumulation in the tissues of the body).