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  2. Clear-cell adenocarcinoma of the vagina - Wikipedia

    en.wikipedia.org/wiki/Clear-cell_adenocarcinoma...

    In the late 1960s through 1971 a cluster of young women, from their teens into their twenties, was mysteriously diagnosed with clear-cell adenocarcinoma (CCA), a cancer not generally found in women until after menopause. Doctors at Massachusetts General Hospital eventually linked DES exposure before birth to the development of CCA in these ...

  3. Carcinoma in situ - Wikipedia

    en.wikipedia.org/wiki/Carcinoma_in_situ

    Carcinoma in situ (CIS) is a group of abnormal cells. [1] [2] While they are a form of neoplasm, [3] there is disagreement over whether CIS should be classified as cancer.This controversy also depends on the exact CIS in question (e.g., cervical, skin, breast).

  4. Vulvar intraepithelial neoplasia - Wikipedia

    en.wikipedia.org/wiki/Vulvar_intraepithelial...

    Vulvar intraepithelial neoplasia (VIN) refers to particular changes that can occur in the skin that covers the vulva. VIN is an intraepithelial neoplasia , and can disappear without treatment. VINs are benign but if the changes become more severe, there is a chance of cancer developing after many years, and so it is referred to as a ...

  5. Squamous cell carcinoma of the vagina - Wikipedia

    en.wikipedia.org/wiki/Squamous_cell_carcinoma_of...

    SCCV has many risk factors in common with cervical cancer and is similarly strongly associated with infection with oncogenic strains of human papillomavirus (HPV). Diagnosis of SCCV is done by pelvic exam and biopsy of the tissue. Treatment and prognosis will depend on the stage, location, and characteristics of the cancer. [1] [2] [3]

  6. Precancerous condition - Wikipedia

    en.wikipedia.org/wiki/Precancerous_condition

    A precancerous condition is a condition, tumor or lesion involving abnormal cells which are associated with an increased risk of developing into cancer. [1] [2] [3] Clinically, precancerous conditions encompass a variety of abnormal tissues with an increased risk of developing into cancer.

  7. Cervical intraepithelial neoplasia - Wikipedia

    en.wikipedia.org/wiki/Cervical_intraepithelial...

    The cause of CIN is chronic infection of the cervix with HPV, especially infection with high-risk HPV types 16 or 18. It is thought that the high-risk HPV infections have the ability to inactivate tumor suppressor genes such as the p53 gene and the RB gene, thus allowing the infected cells to grow unchecked and accumulate successive mutations, eventually leading to cancer.

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  9. Vulvar cancer - Wikipedia

    en.wikipedia.org/wiki/Vulvar_cancer

    Vulvar cancer causes less than 1% of all cancer cases and deaths but around 6% of all gynecologic cancers diagnosed in the UK. Around 1,200 women were diagnosed with the disease in 2011, and 400 women died in 2012. [41] In the United Kingdom 7 out of 10 vulval cancer patients have major surgical resection as part of their cancer treatment.