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A precancerous condition is a condition, tumor or lesion involving abnormal cells which are associated with an increased risk of developing into cancer. [1] [2] [3] Clinically, precancerous conditions encompass a variety of abnormal tissues with an increased risk of developing into cancer.
The cause of CIN is chronic infection of the cervix with HPV, especially infection with high-risk HPV types 16 or 18. It is thought that the high-risk HPV infections have the ability to inactivate tumor suppressor genes such as the p53 gene and the RB gene, thus allowing the infected cells to grow unchecked and accumulate successive mutations, eventually leading to cancer.
The International Classification of Diseases for Oncology (ICD-O) is a domain-specific extension of the International Statistical Classification of Diseases and Related Health Problems for tumor diseases. This classification is widely used by cancer registries. It is currently in its third revision (ICD-O-3). ICD-10 includes a list of ...
The main goal of colposcopy is to prevent cervical cancer by detecting and treating precancerous lesions early. Human Papillomavirus (HPV) is a common infection and the underlying cause for most cervical cancers. Smoking also makes developing cervical abnormalities more likely.
In the late 1960s through 1971 a cluster of young women, from their teens into their twenties, was mysteriously diagnosed with clear-cell adenocarcinoma (CCA), a cancer not generally found in women until after menopause. Doctors at Massachusetts General Hospital eventually linked DES exposure before birth to the development of CCA in these ...
Psychoactive substance-induced psychotic disorders outlined within the ICD-10 codes F10.5—F19.5: F10.5 alcohol: [8] [9] [10] Alcohol is a common cause of psychotic disorders or episodes, which may occur through acute intoxication, chronic alcoholism, withdrawal, exacerbation of existing disorders, or acute idiosyncratic reactions. [8]
Cervical cancer typically develops from precancerous changes called cervical intraepithelial neoplasia over 10 to 20 years. [3] About 90% of cervical cancer cases are squamous cell carcinomas, 10% are adenocarcinoma, and a small number are other types. [4] Diagnosis is typically by cervical screening followed by a biopsy. [2]
Other causes are acquired, such as cervical stenosis, intrauterine adhesions, endometrial cancer, and cervical cancer. [ 3 ] Additionally, hematometra may develop as a complication of uterine or cervical surgery such as endometrial ablation , where scar tissue in the endometrium can "wall off" sections of endometrial glands and stroma causing ...