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One computational method which can be used to calculate IV estimates is two-stage least squares (2SLS or TSLS). In the first stage, each explanatory variable that is an endogenous covariate in the equation of interest is regressed on all of the exogenous variables in the model, including both exogenous covariates in the equation of interest and ...
The use of trapezoidal rule in AUC calculation was known in literature by no later than 1975, in J.G. Wagner's Fundamentals of Clinical Pharmacokinetics. A 1977 article compares the "classical" trapezoidal method to a number of methods that take into account the typical shape of the concentration plot, caused by first-order kinetics. [8]
The Parkland formula, also known as Baxter formula, is a burn formula developed by Charles R. Baxter, used to estimate the amount of replacement fluid required for the first 24 hours in a burn patient so as to ensure the patient is hemodynamically stable.
IV, intravenous; PO, oral route. C is plasma concentration (arbitrary units). Absolute bioavailability compares the bioavailability of the active drug in systemic circulation following non- intravenous administration (i.e., after oral , buccal, ocular, nasal, rectal, transdermal , subcutaneous , or sublingual administration), with the ...
Shockley derives an equation for the voltage across a p-n junction in a long article published in 1949. [2] Later he gives a corresponding equation for current as a function of voltage under additional assumptions, which is the equation we call the Shockley ideal diode equation. [3]
In pharmacology, the volume of distribution (V D, also known as apparent volume of distribution, literally, volume of dilution [1]) is the theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in the blood plasma. [2]
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In chemistry, the iodine value (IV; also iodine absorption value, iodine number or iodine index) is the mass of iodine in grams that is consumed by 100 grams of a chemical substance. Iodine numbers are often used to determine the degree of unsaturation in fats , oils and waxes .