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The total number of digits per sequence is L=100, and the master sequence has a selective advantage of a=1.05. The population of the master sequence as a fraction of the total population (n) as a function of overall mutation rate (1-Q). The total number of digits per sequence is L=100, and the master sequence has a selective advantage of a=1.05.
Temperature-sensitive gene 43 mutants have been identified that have an antimutator phenotype, that is a lower rate of spontaneous mutation than wild type. [7] Studies of one of these mutants, tsB120, showed that the DNA polymerase specified by this mutant copies DNA templates at a slower rate than the wild-type polymerase. [8]
In order to preserve genetic information during cell division, DNA replication must be completed with high fidelity. In order to achieve this task, eukaryotic cells have proteins in place during certain points in the replication process that are able to detect any errors during DNA replication and are able to preserve genomic integrity.
The rate of DNA replication in a living cell was first measured as the rate of phage T4 DNA elongation in phage-infected E. coli. [24] During the period of exponential DNA increase at 37 °C, the rate was 749 nucleotides per second. The mutation rate per base pair per replication during phase T4 DNA synthesis is 1.7 per 10 8. [25]
In molecular biology and biochemistry, processivity is an enzyme's ability to catalyze "consecutive reactions without releasing its substrate". [1]For example, processivity is the average number of nucleotides added by a polymerase enzyme, such as DNA polymerase, per association event with the template strand.
James Dean, who starred in "Rebel Without a Cause" opposite Natalie Wood and "Giant" alongside Elizabeth Taylor and Rock Hudson, died in 1955 at age 24.
RNA polymerase moves down the DNA rapidly at approximately 40 bases per second. Due to the quick nature of this process, DNA is continually unwound ahead of RNA polymerase and then rewound once RNA polymerase moves along further. [18] [1] The polymerase has a proofreading mechanism that limits mistakes to about 1 in 10,000 nucleotides ...
Rep. Mike Lawler argued on Sunday that Republicans considering voting against House Speaker Mike Johnson for another term are “playing with fire.”