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Based on DrugCentral, 1795 human proteins annotated to interact with 2455 approved drugs. [21] Furthermore, it is estimated that only 10-15% of human proteins are disease modifying while only 10-15% are druggable (there is no correlation between the two), meaning that only between 1 and 2.25% of disease modifying proteins are likely to be ...
The Human Proteome Project [1] (HPP) is a collaborative effort coordinated by the Human Proteome Organization. [2] Its stated goal is to experimentally observe all of the proteins produced by the sequences translated from the human genome .
The Human Protein Atlas (HPA) is a Swedish-based program started in 2003 with the aim to map all the human proteins in cells, tissues and organs using integration of various omics technologies, including antibody-based imaging, mass spectrometry-based proteomics, transcriptomics and systems biology.
The depth of the plasma proteome encompasses a dynamic range of more than 10 10 between the highest abundant protein (albumin) and the lowest (some cytokines) and is thought to be one of the main challenges for proteomics. [81] Temporal and spatial dynamics further complicate the study of human plasma proteome.
For 546,000 Swiss-Prot proteins, 44–54% of the proteome in eukaryotes and viruses was found to be "dark", compared with only ~14% in archaea and bacteria. [20] Human proteome. Currently, several projects aim to map the human proteome, including the Human Proteome Map, ProteomicsDB, isoform.io, and The Human Proteome Project (HPP).
Cryptic binding sites are the binding sites that are transiently formed in an apo form or that are induced by ligand binding. Considering the cryptic binding sites increases the size of the potentially “druggable” human proteome from ~40% to ~78% of disease-associated proteins. [29]
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The human interactome is the set of protein–protein interactions (the interactome) that occur in human cells. [ 1 ] [ 2 ] The sequencing of reference genomes, in particular the Human Genome Project , has revolutionized human genetics , molecular biology , and clinical medicine .