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The Asthma Life Impact Scale (ALIS) measure is a disease-specific patient reported outcome questionnaire which assesses the impact that asthma has on a patient’s quality of life. [ 1 ] The questionnaire has 22 items, [ 1 ] which goes beyond earlier focus on the symptoms, functioning and environmental triggers of asthma and includes emotional ...
Asthma is usually triggered by breathing in things in the air such as dust or pollen that produce an allergic reaction. It may be triggered by other things such as an upper respiratory tract infection, cold air, exercise, or smoke. Asthma is a common condition and affects over 300 million people around the world. [3]
Very severe acute asthma (termed "near-fatal" as there is an immediate risk to life) is characterised by a peak flow of less than 33% predicted, oxygen saturations below 92% or cyanosis (blue discoloration, usually of the lips), absence of audible breath sounds over the chest ("silent chest" : wheezing is not heard because there is not enough ...
When queried, asthma patients may report that their first asthma symptoms began after an acute lower respiratory tract illness. This type of history has been labelled the "infectious asthma" (IA) syndrome, [ 133 ] or as "asthma associated with infection" (AAWI) [ 134 ] to distinguish infection-associated asthma initiation from the well known ...
Asthma is a respiratory disease that can begin or worsen due to exposure at work and is characterized by episodic narrowing of respiratory airways. Occupational asthma has a variety of causes, including sensitization to a specific substance, causing an allergic response; or a reaction to an irritant that is inhaled in the workplace.
Furthermore, patients with asthma are found to have an increased release of type II cytokines, especially IL4 and IL5, but a normal or low level of type I cytokine production. Similarly, M. pneumoniae infection promotes a T helper type 2 response, which is why M. pneumoniae -positive patients with asthma have increased airways expression of ...
to diagnose or manage asthma [5] [6] [7] to detect respiratory disease in patients presenting with symptoms of breathlessness, and to distinguish respiratory from cardiac disease as the cause [8] to measure bronchial responsiveness in patients suspected of having asthma [8]
The airways of asthma patients are "hypersensitive" to certain triggers, also known as stimuli (see below). (It is usually classified as type I hypersensitivity.) [4] [5] In response to exposure to these triggers, the bronchi (large airways) contract into spasm (an "asthma attack").
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