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An agglutinin is a substance in the blood that causes particles to coagulate and aggregate; that is, to change from fluid-like state to a thickened-mass (solid) state. [1] Agglutinins can be antibodies that cause antigens to aggregate by binding to the antigen-binding sites of antibodies
The antigens and antibodies combine by a process called agglutination. It is the fundamental reaction in the body by which the body is protected from complex foreign molecules, such as pathogens and their chemical toxins. In the blood, the antigens are specifically and with high affinity bound by antibodies to form an antigen-antibody complex.
Agglutinogen is an antigen [1] that causes the formation of agglutinins in the body and leads to agglutination, such as hemagglutination, which involves red blood cells (RBCs). The kind of agglutinogens present on the red blood cells helps determine the blood type of a person. [2]
This image explains agglutination in the blood. Agglutination is the clumping of particles. The word agglutination comes from the Latin agglutinare (glueing to).. Agglutination is a reaction in which particles (as red blood cells or bacteria) suspended in a liquid collect into clumps usually as a response to a specific antibody.
Blood compatibility testing is routinely performed before a blood transfusion.The full compatibility testing process involves ABO and RhD (Rh factor) typing; screening for antibodies against other blood group systems; and crossmatching, which involves testing the recipient's blood plasma against the donor's red blood cells as a final check for incompatibility.
It does not identify the Rh(D) antigen (Rh blood type). The bedside card method of blood grouping relies on visual agglutination to determine an individual's blood group. The card contains dried blood group antibody reagents fixed onto its surface. A drop of the individual's blood is placed on each blood group area on the card.
There is an agglutination reaction between similar antigen and antibody (for example, antigen A agglutinates the antibody A and antigen B agglutinates the antibody B). Thus, transfusion can be considered safe as long as the serum of the recipient does not contain antibodies for the blood cell antigens of the donor.
Cold agglutinins are antibodies, typically immunoglobulin M (), that are acquainted with and then binding the antigens on red blood cells, typically antigens "I" or "i" on the RBC surface, [1] in the environment in which the temperatures are lower than normal core body temperature and, thus, ends up leading to agglutinations of the red blood cells and hemolysis reaction occurring outside the ...