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The natural, plant-derived progesterone creams sold over the counter contain too little progesterone to be effective. Wild yam (Dioscorea villosa) extract creams are not effective since the natural progesterone present in the extract is not bioavailable. [27]
There is little modern clinical research on Dioscorea villosa, and the one study of a wild yam-containing cream for menopausal symptoms failed to find any value from this therapy. [18] According to the American Cancer Society, there is no evidence to support wild yam or diosgenin being either safe or effective in humans. [19]
[8] [irrelevant citation] Wild yams are an important crop, as they have been used to prevent menstrual cramps, stomach cramps, and general pain for centuries. During the 1950s scientists found that the roots of wild yams contained diosgenin which is a plant-based estrogen; diosgenin is hypothesized to aid in chemical defense against herbivores.
Creams. Conjugated estrogens (Premarin) – 0.625 mg/g (0.0625%) ... For Women: Menopause—Medicines to Help You – U.S. Food and Drug Administration
Dioscorea sericea (common names: wild yam, colic-root, rheumatism-root) [2] is a type of climbing tuberous geophyte in the family Dioscoreaceae. [3] It is native to Colombia and Peru . [ 1 ]
Dioscorea dregeana, the wild yam, is a perennial creeper that is native to the eastern parts of southern Africa. [1] It is commonly used and traded as a traditional medicine, or muti . [ 1 ]
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