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Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells , but also acts on haemopoietic progenitor cells and T cells .
Hepatocyte growth factor activator is a protein that in humans is encoded by the HGFAC gene. [5] [6] [7]The protein encoded by this gene, belongs to peptidase family S1. It is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing.
The transforming growth factor receptor 3 (TGFβR3) is the most abundant of the TGF-β receptors yet, [14] it has no known signaling domain. [15] It however may serve to enhance the binding of TGFβ ligands to TGFβ type II receptors by binding TGFβ and presenting it to TGFβR2.
A growth factor is a naturally occurring substance capable of stimulating cell proliferation, wound healing, and occasionally cellular differentiation. [1] Usually it is a secreted protein or a steroid hormone .
9146 15239 Ensembl ENSG00000185359 ENSMUSG00000025793 UniProt O14964 Q99LI8 RefSeq (mRNA) NM_004712 NM_001159328 NM_008244 RefSeq (protein) NP_004703 NP_001152800 NP_032270 Location (UCSC) Chr 17: 81.68 – 81.7 Mb Chr 11: 120.36 – 120.37 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Hepatocyte growth factor-regulated tyrosine kinase substrate is an enzyme that in humans is ...
Human hepatocyte growth factor (HGF) is an 80kD [1] pleiotropic protein that is endogenously produced by a variety of cell types from the mesenchymal cell lineage (such as cardiomyocytes and neurons). [4] It is produced and proteolytically cleaved to its active state in response to cellular injury or during apoptosis.
The typical hepatocyte is cubical with sides of 20-30 μm, (in comparison, a human hair has a diameter of 17 to 180 μm). [1] The typical volume of a hepatocyte is 3.4 x 10 −9 cm 3. [2] Smooth endoplasmic reticulum is abundant in hepatocytes, in contrast to most other cell types. [3]
Hepatocyte growth factor receptor (HGF receptor) [5] [6] is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity. [ 7 ] The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor.
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