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When the blood vessels suddenly relax, it results in vasodilation. In vasodilatory shock, the blood vessels are too relaxed leading to extreme vasodilation and blood pressure drops and blood flow becomes very low. Without enough blood pressure, blood and oxygen will not be pushed to reach the body's organs.
The primary function of vasodilation is to increase blood flow in the body to tissues that need it most. This is often in response to a localized need for oxygen but can occur when the tissue in question is not receiving enough glucose, lipids, or other nutrients. Vasodilation, both localized and systemic, also facilitates immune response. [7]
Hyperdynamic circulation is abnormally increased circulatory volume. Systemic vasodilation and the associated decrease in peripheral vascular resistance results in decreased pulmonary capillary wedge pressure and decreased blood pressure, presenting usually with a collapsing pulse, but sometimes a bounding pulse.
Obstructive shock is a form of shock associated with physical obstruction of the great vessels of the systemic or pulmonary circulation. [13] Several conditions can result in this form of shock. Cardiac tamponade, in which fluid in the pericardium prevents inflow of blood into the heart (venous return). [9]
The cause of inadequate tissue perfusion (blood delivery to tissues) in distributive shock is a lack of normal responsiveness of blood vessels to vasoconstrictive agents and direct vasodilation. [4] There are four types of distributive shock.
These changes contribute to the progression of vascular diseases. [4] In a healthy state, the endothelium exhibits vasodilation, tightly controlled vascular permeability, and anti-thrombotic and anti-inflammatory properties. This balance ensures the smooth functioning of the vascular system.
Instantaneous hypotension due to sudden, massive vasodilation and decrease in blood oxygen saturation; Warm, flushed skin due to vasodilation and inability to constrict blood vessels. Priapism, also due to vasodilation; The patient will be unable to mount a tachycardic response, and often becomes bradycardic
A systemic disease is one that affects a number of organs and tissues, or affects the body as a whole. [1] It differs from a localized disease , which is a disease affecting only part of the body (e.g., a mouth ulcer ).