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Fluorouracil (5-FU, 5-fluorouracil), sold under the brand name Adrucil among others, is a cytotoxic chemotherapy medication used to treat cancer. [3] By intravenous injection it is used for treatment of colorectal cancer , oesophageal cancer , stomach cancer , pancreatic cancer , breast cancer , and cervical cancer . [ 3 ]
While topical 5-FU is a widely used and cost-effective treatment for AKs and is generally well tolerated, its potential side-effects can include: pain, crusting, redness, and local swelling. [55] These adverse effects can be mitigated or minimized by reducing the frequency of application or taking breaks between uses. [ 55 ]
Acral erythema is a common adverse reaction to cytotoxic chemotherapy drugs, particularly cabozantinib, cytarabine, doxorubicin, and fluorouracil and its prodrug capecitabine. [ 3 ] Targeted cancer therapies , especially the tyrosine kinase inhibitors sorafenib and sunitinib , have also been associated with a high incidence of acral erythema.
A 5% 5-fluorouracil (5-FU) cream was used, but it is no longer considered an acceptable treatment due to the side-effects. [28] Podophyllin, podofilox and isotretinoin should not be used during pregnancy, as they could cause birth defects in the fetus.
Possible side effects include necrosis of the digits, nail loss, and Raynaud syndrome. The usual treatment is one or two injections. [18] [19] Immunotherapy, as intralesional injection of antigens (mumps, candida or trichophytin antigens USP), is a wart treatment that may trigger a host immune response to the wart virus, resulting in wart ...
In people with psoriasis using topical steroids it occurs in up to 5% of people after a year of use. [5] Intermittent use of topical steroids for atopic dermatitis is safe and does not cause skin thinning. [6] [7] [8] Skin atrophy can occur with both prescription and over the counter steroids creams. [9]
Don't rely on bloviating pundits to tell you who'll prevail on Hollywood's big night. The Huffington Post crunched the stats on every Oscar nominee of the past 30 years to produce a scientific metric for predicting the winners at the 2013 Academy Awards.
Imiquimod is a patient-applied cream prescribed to treat genital warts, Bowens disease (squamous cell carcinoma in situ), and, secondary to surgery, for basal cell carcinoma, [7] [8] as well as actinic keratosis. [9] Imiquimod 5% cream is indicated for the topical treatment of: external genital and perianal warts (condylomata acuminata) in ...