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Loperamide, sold under the brand name Imodium, among others, [1] is a medication of the opioid receptor agonist class used to decrease the frequency of diarrhea. [ 5 ] [ 4 ] It is often used for this purpose in irritable bowel syndrome , inflammatory bowel disease , short bowel syndrome , [ 4 ] Crohn's disease , and ulcerative colitis . [ 5 ]
Antimotility agents are drugs used to alleviate the symptoms of diarrhea. These include loperamide (Imodium), bismuth subsalicylate (Pepto-Bismol), [1] diphenoxylate with atropine (Lomotil), and opiates such as paregoric, tincture of opium, codeine, and morphine.
Nifuroxazide is an oral nitrofuran antibiotic, patented since 1966 [1] and used to treat colitis and diarrhea in humans and non-humans. [2] It is sold under the brand names Ambatrol, Antinal, Bacifurane, Diafuryl (Turkey), Benol (Pakistan), Pérabacticel (France), Antinal, Diax (Egypt), Nifrozid, Ercefuryl (Romania, Czech Republic, Russia), Erfuzide (Thailand), Endiex (Slovakia), Enterofuryl ...
It contains loperamide and simethicone. Loperamide is a μ-opioid receptor agonist that works in the intestines. [1] Although it is an opioid, it has no effects on the central nervous system. It reduces diarrhea by slowing the transit time of contents through the intestinal tract thereby allowing more water to be reabsorbed from the intestinal ...
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In November 1993 Imodium Lingual from Janssen Pharmaceutica was released in Germany with Zydis technology. [ 4 ] In December, 1996, the Food and Drug Administration approved Claritin ( loratadine ) RediTabs from Schering-Plough , the first prescription drug with Zydis technology sold in the U.S. [ 5 ]
Racecadotril is used for the treatment of acute diarrhea in children and adults and has better tolerability than loperamide, as it causes less constipation and flatulence. [6] [7] Several guidelines have recommended racecadotril use in addition to oral rehydration treatment in children with acute diarrhea. [8]
The combination is generally safe for short-term use and with recommended dosage. In doses used for the treatment of diarrhea, whether acute or chronic, diphenoxylate has not produced addiction. It may cause several side-effects, such as dry mouth, headache, constipation and blurred vision. It is not recommended for children under six years of age.