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Mirtazapine is sometimes described as a noradrenergic and specific serotonergic antidepressant (NaSSA), [11] although the actual evidence in support of this label has been regarded as poor. [17] It is a tetracyclic piperazine-azepine. [85] Mirtazapine has antihistamine, α 2-blocker, and antiserotonergic activity.
People also may not remember where their home is or the loved ones who take care of them, Dr. Kobylarz says. “You can see [the person with dementia] change at a certain time of the day and ...
Chemical structure of the prototypical NaSSA mirtazapine (original brand name Remeron). Noradrenergic and specific serotonergic antidepressants (NaSSAs) are a class of psychiatric drugs used primarily as antidepressants. [1]
It has also been suggested that mirtazapine has no significant serotonergic effects and is therefore not a dual action drug. [34] Bupropion has also been suggested to cause SS, [35] [36] although as there is no evidence that it has any significant serotonergic activity, it is thought unlikely to produce the syndrome. [37]
The tetracyclic antidepressants mianserin and mirtazapine are α 2 blockers, although their efficacy as antidepressants may come from their activity at other receptor sites. [citation needed] Mechanistically, α 2 blockers increase adrenergic, dopaminergic and serotonergic neurotransmitters and induce insulin secretion, decreasing blood sugar ...
A study published in 2019 of more than 7,700 English adults over 50 found people who report experiencing ageism are more likely to say they are in poor health or have symptoms of depression.
As we age, our brain experiences both structural and functional changes. Over time, this can cause a decline in cognitive abilities, memory, and even emotional regulation. Certain lifestyle ...
People may also be switched to the long-acting antidepressant fluoxetine, which can then be gradually decreased. [12] Approximately 20–50% of people who suddenly stop an antidepressant develop an antidepressant discontinuation syndrome. [187] [13] [188] The condition is generally not serious. [187]