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Nizatidine is a histamine H 2 receptor antagonist that inhibits stomach acid production, and is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease. [ 2 ] It was patented in 1980 and approved for medical use in 1988.
The song consists of a long list of sexually transmitted diseases contracted during a "lovely night in June" and their unpleasant effects on the body, [1] using medical terminology provided by Graham Chapman, who was a qualified doctor. [2] The song was included as an animated number in A Liar's Autobiography, during the end credits.
Ranitidine has 10% of the affinity that cimetidine has to CYP450, so it causes fewer side effects, but other H 2 blockers famotidine and nizatidine have no CYP450 significant interactions. [131] Ranitidine was introduced in 1981, and was the world's biggest-selling prescription drug by 1987. [132]
Cimetidine was the prototypical histamine H 2 receptor antagonist from which later drugs were developed. Cimetidine was the culmination of a project at Smith, Kline & French (SK&F; now GlaxoSmithKline) by James W. Black, C. Robin Ganellin, and others to develop a histamine receptor antagonist that would suppress stomach acid secretion.
"Lovesong" (sometimes written as "Love Song") is a song by English rock band the Cure, released as the third single from their eighth studio album, Disintegration (1989), on 21 August 1989. The song saw considerable success in the United States, where it reached the number-two position in October 1989 and became the band's only top-10 entry on ...
The H 2 receptor antagonists are a class of drugs used to block the action of histamine on parietal cells in the stomach, decreasing the production of acid by these cells. H 2 antagonists are used in the treatment of dyspepsia, although they have been surpassed in popularity by the more effective [1] proton pump inhibitors.
The song debuted on the UK Singles Chart at number 30 and later peaked at number four. The song debuted at number 100 on the Canadian Hot 100 the week of January 31, 2008, and reached number one on the chart the week of March 29, 2008. In Australia, "Love Song" peaked at number four during its ninth week on the country's chart.
Shannon Carlin of Radio.com described the style of Love Songs Drug Songs as being "in the vein of old '60s soul, '90s R&B, and funk". [2] Matt Collar of AllMusic stated, "Musically, X Ambassadors build a percussive mix of synthesizers, booming drums, and atmospheric guitar lines around vocalist Sam Harris' yearning, robust cry" while revealing "their love for mixing contemporary R&B ...