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Other causes of peptic ulcer disease include gastric ischaemia, drugs, metabolic disturbances, cytomegalovirus (CMV), upper abdominal radiotherapy, Crohn's disease, and vasculitis. [15] Gastrinomas (Zollinger–Ellison syndrome), or rare gastrin-secreting tumors, also cause multiple and difficult-to-heal ulcers. [34]
The key to management and prognosis is identifying the cause or causes of the underlying constipation. Patients should be encouraged to increase fiber , fluids , and fruits in their habits. Osmotic and stimulant laxatives can also be considered to aid patients if they have trouble making the necessary changes to their diet.
F. Reigel suggests that ulcers are caused by excess acid. [1] Bacillus coli (E. coli) 1906 Krienitz finds bacteria in the stomach of people with gastric cancer. [2] Turck feeds dogs Bacillus coli and produces ulcers. [7] 1907 Berkley Moynihan suggests that acid is a cause of ulcers. [1] 1910
Prolonged bleeding may cause anemia leading to weakness and fatigue. Inflammation of the pyloric antrum, which connects the stomach to the duodenum, is more likely to lead to duodenal ulcers, while inflammation of the corpus may lead to a gastric ulcer. Stomach cancer can cause nausea, vomiting, diarrhoea, constipation, and unexplained weight ...
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Causes of constipation may include faecal impaction and bowel obstruction, which may in turn be caused by ileus, intussusception, volvulus. Inflammatory bowel disease is a condition of unknown aetiology, classified as either Crohn's disease or ulcerative colitis , that can affect the intestines and other parts of the gastrointestinal tract.
While the causes of IBS are still unknown, it is believed that the entire gut–brain axis is affected. [30] [31] Recent findings suggest that an allergy triggered peripheral immune mechanism may underlie the symptoms associated with abdominal pain in patients with irritable bowel syndrome. [32] IBS is more prevalent in obese patients. [33]
Causes of gastric outlet obstruction include both benign causes, such as peptic ulcer disease affecting the area around the pylorus, and malignant causes, such as gastric cancer. Causation related to ulcers may involve severe pain which the patient may interpret as a heart condition or attack.