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The Enzyme Commission refers to this family as SARS coronavirus main proteinase (M pro; EC 3.4.22.69). The 3CL protease corresponds to coronavirus nonstructural protein 5 (nsp5). The "3C" in the common name refers to the 3C protease (3C pro ) which is a homologous protease found in picornaviruses .
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[b] The COVID-19 pandemic also saw the emergence of misinformation and conspiracy theories, [39] and highlighted weaknesses in the U.S. public health system. [17] [40] [41] In the United States, there have been 103,436,829 [3] confirmed cases of COVID-19 with 1,216,003 [3] confirmed deaths, the most of any country, and the 17th highest per ...
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The M protein is a transmembrane protein with three transmembrane domains and is around 230 amino acid residues long. [8] [9] In SARS-CoV-2, the causative agent of COVID-19, the M protein is 222 residues long. [10] Its membrane topology orients the C-terminus toward the cytosolic face of the membrane and thus into the interior of the virion.
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Spike (S) glycoprotein (sometimes also called spike protein, [2] formerly known as E2 [3]) is the largest of the four major structural proteins found in coronaviruses. [4] The spike protein assembles into trimers that form large structures, called spikes or peplomers, [3] that project from the surface of the virion.
The true COVID-19 death toll in the United States would therefore be higher than official reports, as modeled by a paper published in The Lancet Regional Health – Americas. [3] One way to estimate COVID-19 deaths that includes unconfirmed cases is to use the excess mortality , which is the overall number of deaths that exceed what would ...