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  2. Tetrabenazine - Wikipedia

    en.wikipedia.org/wiki/Tetrabenazine

    Tetrabenazine is a drug for the symptomatic treatment of hyperkinetic movement disorders.It is sold under the brand names Nitoman and Xenazine among others. On August 15, 2008, the U.S. Food and Drug Administration approved the use of tetrabenazine to treat chorea associated with Huntington's disease.

  3. Huntingtin - Wikipedia

    en.wikipedia.org/wiki/Huntingtin

    Huntingtin (Htt) is the protein coded for in humans by the HTT gene, also known as the IT15 ("interesting transcript 15") gene. [5] Mutated HTT is the cause of Huntington's disease (HD), and has been investigated for this role and also for its involvement in long-term memory storage. [6]

  4. Huntington's disease - Wikipedia

    en.wikipedia.org/wiki/Huntington's_disease

    Huntington's disease (HD), also known as Huntington's chorea, is an incurable neurodegenerative disease [7] that is mostly inherited. [8] The earliest symptoms are often subtle problems with mood or mental/psychiatric abilities. [9] [1] A general lack of coordination and an unsteady gait often follow. [2]

  5. Branaplam - Wikipedia

    en.wikipedia.org/wiki/Branaplam

    Branaplam (development codes LMI070 and NVS-SM1) is a pyridazine derivative that is being studied as an experimental drug.It was originally developed by Novartis to treat spinal muscular atrophy (SMA); since 2020 it was being developed to treat Huntington's disease but the trial ended in 2023 due to toxicity concerns.

  6. Chorea - Wikipedia

    en.wikipedia.org/wiki/Chorea

    Treatment; Huntington's-related: A common treatment is dopaminergic antagonists, although treatment is largely supportive. Tetrabenazine, deutetrabenazine and valbenazine are FDA-approved drugs for the treatment of Huntington's disease-related chorea. Sydenham's chorea: Haloperidol, carbamazepine and valproic acid.

  7. Basal ganglia disease - Wikipedia

    en.wikipedia.org/wiki/Basal_ganglia_disease

    Huntington's disease is a hereditary disease that causes defects in behavior, cognition, and uncontrolled rapid, jerky movements. [1] Huntington's disease stems from a defect that consists of an expanded CAG repeat in the huntingtin gene (HTT) located on the short arm p of chromosome 4 . [ 7 ]

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