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Praziquantel is well absorbed (about 80%) from the gastrointestinal tract. However, due to extensive first-pass metabolism, only a relatively small amount enters systemic circulation. Praziquantel has a serum half-life of 0.8 to 1.5 hours in adults with normal renal and liver function. Metabolites have a half-life of 4 to 5 hours.
It contains esafoxolaner, an aryl isoxazoline; eprinomectin, an avermectin anthelmintic; and praziquantel, a pyrazinoisoquinoline anthelmintic. [ 3 ] Veterinary uses
Oxamniquine is a semisynthetic tetrahydroquinoline and possibly acts by DNA binding, resulting in contraction and paralysis of the worms and eventual detachment from terminal venules in the mesentry, and death. Its biochemical mechanisms are hypothesized to be related to an anticholinergic effect, which increases the parasite's motility, as ...
praziquantel – treatment of infestations of the tapeworms Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus prazosin – sympatholytic used in hypertension and abnormal muscle contractions
Continuous dewormers, also known as "daily" dewormers, are given in the horse's feed each day, in small doses, and kill worms as they infect the horse. Neither of these methods is perfect; purge dewormers are effective for rapidly killing parasites, but are gone from the horses' body in a few days, and then the horse may start to be re-infected.
Avermectins (including ivermectin and moxidectin) - effective against most common intestinal worms, except tapeworms, for which praziquantel is commonly used in conjunction for mass dewormings; Drugs not members of these three main categories include: Diethylcarbamazine – effective against Wuchereria bancrofti, Brugia malayi, Brugia timori ...
It works by paralyzing worms. [4] Pyrantel was initially described in 1965. [5] It is on the World Health Organization's List of Essential Medicines. [6] Pyrantel is available as a generic medication. [4] It may also be used to treat worms in a number of other animals. [5]
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