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Initial reports questioned whether this was a true medical disorder, or whether the inflammation was secondary to another condition, such as gastroesophageal reflux disease. The cause of lymphocytic esophagitis is unknown. The disease may cause different symptoms and be caused by different processes in childhood as compared to adulthood.
Esophagitis can be asymptomatic; or can cause epigastric and/or substernal burning pain, especially when lying down or straining; and can make swallowing difficult . The most common cause of esophagitis is the reverse flow of acid from the stomach into the lower esophagus: gastroesophageal reflux disease (GERD). [2]
Gastroesophageal reflux disease (GERD) or gastro-oesophageal reflux disease (GORD) is a chronic upper gastrointestinal disease in which stomach content persistently and regularly flows up into the esophagus, resulting in symptoms and/or complications.
Esophageal diseases can derive from congenital conditions, or they can be acquired later in life. Many people experience a burning sensation in their chest occasionally, caused by stomach acids refluxing into the esophagus , normally called heartburn.
Sandifer syndrome (or Sandifer's syndrome) is an eponymous paediatric medical disorder, characterised by gastrointestinal symptoms and associated neurological features. [1] [2] [3] There is a significant correlation between the syndrome and gastro-oesophageal reflux disease (GORD); however, it is estimated to occur in less than 1% of children ...
Acid peptic diseases, such as peptic ulcers, Zollinger-Ellison syndrome, and gastroesophageal reflux disease, are caused by distinct but overlapping pathogenic mechanisms involving acid effects on mucosal defense. Acid reflux damages the esophageal mucosa and may also cause laryngeal tissue injury, leading to the development of pulmonary ...
Although many of these symptoms overlap with the symptoms of GERD, the majority of patients with EoE exhibit a poor response to acid-suppression therapy. [6] Many people with EoE have other autoimmune and allergic diseases such as asthma [3] and celiac disease. [7]
Gastroesophageal reflux disease can cause acid erosion of the teeth and halitosis. Gardner's syndrome can be associated with failure of tooth eruption, supernumerary teeth, and dentigerous cysts. Peutz–Jeghers syndrome can cause dark spots on the oral mucosa or on the lips or the skin around the mouth.