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Pagetoid is a term used in dermatology to refer to "upward spreading" of abnormal cells in the epidermis (ie from bottom to top). It is uncommon and a possible indication of a precancerous or cancerous condition. Cells display pagetoid growth when they invade the upper epidermis from below.
Download as PDF; Printable version; ... Dermatology: Atypical lichen myxedematosus is a skin condition caused by fibroblasts producing abnormally large amounts of ...
Dermatology Atypical tuberous myxedema , also known as Jadassohn–Dosseker syndrome, is thought to represent a pure nodular variant of lichen myxedematosus . [ 1 ]
Apoptotic and necrotic cells, absence of acantholytic cells A Tzanck smear may be a rapid test to distinguish toxic epidermal necrolysis from SSSS III. Genodermatoses: Hailey-Hailey disease: Acantholytic cells without direct immunofluorescence positivity Direct immunofluorescence examination should be made for differentiation from pemphigus.
Marked atypia of type 2 pneumocytes is a characteristic finding in association with treatment with busulfan and other chemotherapeutic agents.. Atypia (from Greek, a + typos, without type; a condition of being irregular or nonstandard) [1] is a histopathologic term for a structural abnormality in a cell, i.e. it is used to describe atypical cells.
Atypical fibroxanthoma (AFX) of the skin is a low-grade malignancy related to malignant fibrous histiocytoma, which it resembles histologically. [ 2 ] : 613 Atypical fibroxanthoma manifests as a hard, pink or red papule or nodule that grows over the course of several months and may bleed or ulcerate .
Dysplastic nevus (atypical mole, atypical nevus, B-K mole, Clark's nevus, dysplastic melanocytic nevus, nevus with architectural disorder) Dysplastic nevus syndrome (B-K mole syndrome, familial atypical multiple mole–melanoma syndrome, familial melanoma syndrome) Ephelis (freckle) Epithelioid blue nevus; Generalized lentiginosis
Large melanocytic cells with nest formation along the dermo-epidermal junction. Invasion of the upper epidermis in a pagetoid fashion (discohesive single cell growth). The pattern of rete ridges is often effaced. Invasion of the dermis by atypical, pleomorphic melanocytes; Absence of the 'maturation' typical of naevus cells; Mitoses