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The nucleolus (/ nj uː ˈ k l iː ə l ə s, ˌ nj uː k l i ˈ oʊ l ə s /; pl.: nucleoli /-l aɪ /) is the largest structure in the nucleus of eukaryotic cells. [1] It is best known as the site of ribosome biogenesis. The nucleolus also participates in the formation of signal recognition particles and plays a role in the cell's response to ...
In fact, DNA analysis of these two types of domains have shown that many sequences overlap, indicating that certain regions may switch between lamina-binding and nucleolus-binding. [35] NADs are associated with nucleolus function. The nucleolus is the largest sub-organelle within the nucleus and is the principal site for rRNA transcription.
Nuclear bodies include Cajal bodies, the nucleolus, nuclear speckles (also called splicing speckles), histone locus bodies, and promyelocytic leukemia protein (PML) nuclear bodies (also called PML oncogenic dots). [2] Nuclear bodies also include ND10s. ND stands for nuclear domain, and 10 refers to the number of dots seen. [3]
A nucleolar detention center (DC) is a region of the cell in which certain proteins are temporarily detained in periods of cellular stress. [1] DCs are absent from cells under normal culture conditions, but form in response to specific environmental triggers.
P80-coilin is a specific marker for coiled bodies, [9] and demonstrates these bodies tend to be associated with the nucleolus when cells are not dividing. CBs are associated with telomerase assembly and recruitment via a CAB-RNA sequence common in both CB RNAs ( scaRNAs ) and the RNA component of telomerase (TERC).
Getti found that in addition to the nucleoplasm, the hnRNPI was staining a “discrete unidentified structure” always opposite of the nucleoli. In 1995, A. Gregory Matera et al. first gave the structure its name “perinucleolar compartment” after finding several RNA polymerase III transcripts as well as hnRNPI at the nucleolar rim. [3]
The nucleolus is the largest of the discrete densely stained, membraneless structures known as nuclear bodies found in the nucleus. It forms around tandem repeats of rDNA, DNA coding for ribosomal RNA (rRNA). These regions are called nucleolar organizer regions (NOR). The main roles of the nucleolus are to synthesize rRNA and assemble ribosomes ...
The location of NORs and the nucleolar cycle in human cells. Nucleolus organizer regions (NORs) are chromosomal regions crucial for the formation of the nucleolus.In humans, the NORs are located on the short arms of the acrocentric chromosomes 13, 14, 15, 21 and 22, the genes RNR1, RNR2, RNR3, RNR4, and RNR5 respectively. [1]