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Synaptic pruning, a phase in the development of the nervous system, is the process of synapse elimination that occurs between early childhood and the onset of puberty in many mammals, including humans. [1] Pruning starts near the time of birth and continues into the late-20s. [2]
[1] [2] [3] This phenomenon is a result of neuroplasticity, including Hebbian learning [4] [5] and synaptic pruning. [2] Through these mechanisms, neural pathways that are more consistently used are strengthened, making them more efficient, while those pathways that are unused become less efficient.
Early life stress is believed to produce changes in brain development by interfering with neurogenesis, synaptic production, and pruning of synapses and receptors. [58] Interference with these processes could result in increased or decreased brain region volumes, potentially explaining the findings that early life stress is associated with ...
This is an activity-dependent event. Partial blockage of the receptor leads to retraction of corresponding presynaptic terminals. Later they used a connectomic approach, i.e., tracing out all the connections between motor neurons and muscle fibers, to characterize developmental synapse elimination on the level of a full circuit.
Diagram of a chemical synaptic connection. In the nervous system, a synapse [1] is a structure that allows a neuron (or nerve cell) to pass an electrical or chemical signal to another neuron or a target effector cell.
Pruning is the practice of removing parameters (which may entail removing individual parameters, or parameters in groups such as by neurons) from an existing artificial neural networks. [1] The goal of this process is to maintain accuracy of the network while increasing its efficiency .
The process of synaptic pruning known as synapse elimination is a presumably activity-dependent process that involves competition between axons. Hypothetically, a synapse strong enough to produce an action potential will trigger the myonuclei directly across from the axon to release synaptotrophins that will strengthen and maintain well ...
It describes the discovery of synaptic pruning and its current relevance to early learning, autism, schizophrenia and Alzheimer's disease. The book centers on the intriguing life story of the discoverer of synaptic pruning, her father Peter Huttenlocher, and also discusses the physician-scientist career path.