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The percentage of dead osteocytes in bone increases with age from less than 1% at birth to 75% after age 80. [23] Osteocyte apoptosis is thought to be related to decreased mechanotransduction, which possibly leads to the development of osteoporosis. [24] Apoptotic osteocytes release apoptotic bodies expressing RANKL to recruit osteoclasts. [12]
Diagram of a typical long bone showing both cortical (compact) and cancellous (spongy) bone. Haversian canals [i] (sometimes canals of Havers, osteonic canals or central canals) are a series of microscopic tubes in the outermost region of bone called cortical bone. They allow blood vessels and nerves to travel through them to supply the osteocytes.
Diagram of a typical long bone showing both compact (cortical) and cancellous (spongy) bone. Osteons on cross-section of a bone. In osteology, the osteon or haversian system (/ h ə ˈ v ɜːr. ʒ ən /; named for Clopton Havers) is the fundamental functional unit of much compact bone.
Materials picked up by osteocytes adjacent to blood vessels are distributed throughout the bone matrix via the canaliculi. Diameter of canaliculi in human bone is approximately 200 to 900 nm. [ 1 ] In bovine tibia diameter of canaliculi was found to vary from 155 to 844 nm (average 426 nm). [ 2 ]
Micrograph of cancellous bone. Cancellous bone or spongy bone, [12] [11] also known as trabecular bone, is the internal tissue of the skeletal bone and is an open cell porous network that follows the material properties of biofoams. [13] [14] Cancellous bone has a higher surface-area-to-volume ratio than cortical bone and it is less dense. This ...
As calcium binds to the osteoid, the matrix hardens, and the osteoblasts become entrapped, transforming into osteocytes. As osteoblasts continue to secrete osteoid, it surrounds blood vessels, leading to the formation of trabecular (cancellous or spongy) bone. These blood vessels will eventually develop into red bone marrow.
In an ordinary microscopic section, viewed by transmitted light, they appear as fusiform opaque spots. Each lacuna is occupied during life by a branched cell, termed an osteocyte, bone-cell or bone-corpuscle. Lacunae are connected to one another by small canals called canaliculi. A lacuna never contains more than one osteocyte.
Located in the main shaft of a long bone (consisting mostly of compact bone), the medullary cavity has walls composed of spongy bone (cancellous bone) and is lined with a thin, vascular membrane . [1] [2] This area is involved in the formation of red blood cells and white blood cells, and the calcium supply for bird eggshells. The area has been ...