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Nevertheless, PDE5 inhibitors already marketed for erectile dysfunction and pulmonary arterial hypertension are undergoing research in several conditions such as resistant hypertension, myocardial infarction, heart failure, intermittent claudication, Raynaud's phenomenon, chronic kidney disease, and diabetes mellitus due to our greater ...
For example, one study published in 2014 in the journal Biochemical and Biophysical Research Communications found that oral use of the amino acids L-arginine and L-citrulline — the two amino ...
These phosphodiesterase inhibitors are used primarily as remedies for erectile dysfunction, as well as having some other medical applications such as treatment of pulmonary hypertension. Dipyridamole also inhibits PDE5. This results in added benefit when given together with nitric oxide or statins.
Tadalafil (marketed as Cialis) is a PDE5 inhibitor used to treat erectile dysfunction [23] and pulmonary arterial hypertension. [24] It has a longer half life than sildenafil of 17.5 hours, allowing it to be taken once a day. [24] Tadalafil "daily" (5 mg) is also used for treatment of benign prostate hyperplasia. [25]
L-arginine supplementation (or even nitric oxide supplements like nitrates) is typically not the most efficient way to produce nitric oxide, which is why people may use L-citrulline supplements to ...
Sildenafil, sold under the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. [4] [8] It is also sometimes used off-label for the treatment of certain symptoms in secondary Raynaud's phenomenon. [9] It is unclear if it is effective for treating sexual dysfunction in females. [8]
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