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Medetomidine. Medetomidine is a veterinary anesthetic drug with potent sedative effects and emerging illicit drug adulterant. It is a racemic mixture of two stereoisomers, levomedetomidine and dexmedetomidine, the latter being the isomer with the pharmacologic effect as an alpha 2- adrenergic agonist. Effects can be reversed using atipamezole.
Atipamezole. Atipamezole , sold under the brand name Antisedan among others, is a synthetic α 2 adrenergic receptor antagonist used for the reversal of the sedative and analgesic effects of dexmedetomidine and medetomidine in dogs. Its reversal effect works by competing with the sedative for α 2 -adrenergic receptors and displacing them.
Medetomidine, a powerful animal tranquilizer, has emerged as one of the latest substances found mixed with other common street drugs. The drug has recently been cited as the likely culprit behind ...
The treatment and management of COVID-19 combines both supportive care, which includes treatment to relieve symptoms, fluid therapy, oxygen support as needed, [1][2][3] and a growing list of approved medications. Highly effective vaccines have reduced mortality related to SARS-CoV-2; however, for those awaiting vaccination, as well as for the ...
The rise of medetomidine comes as overdose deaths have fallen slightly. More than 107,000 people died of a drug overdose last year, down from about 111,000 in 2022, according to a recent report.
Medetomidine’s entry in the state further challenges what health officials term "harm reduction" efforts, Niesen said, or how to engage people who use drugs with better safety measures. It ...
The drug repurposing analysis that was first to propose a steroid for severe COVID-19 case was eventually published in the journal Bioinformatics [185] Currently, steroids including methylprednisolone and dexamethasone are part of the standard of care in severe cases of COVID-19.
Alpha-2 blockers (or α2 blockers) are a subset of the alpha blocker class of drugs and are antagonists to the α 2 adrenergic receptor. They are mainly used in research, having found limited clinical application in human medicine. They are extensively used in veterinary medicine to reverse the effects of alpha-2 agonist drugs used as sedatives ...