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Albuminuria is a pathological condition wherein the protein albumin is abnormally present in the urine (>30 mg per day). It is a type of proteinuria.Albumin is a major plasma protein (normally circulating in the blood); in healthy people, only trace amounts of it are present in urine, whereas larger amounts occur in the urine of patients with kidney disease.
The level of albumin protein produced by microalbuminuria can be detected by special albumin-specific urine dipsticks, which have a lower detection threshold than standard urine dipsticks. A microalbumin urine test determines the presence of the albumin in urine. In a properly functioning body, albumin is not normally present in urine because ...
Because the test pad reaction is dependent on pH, false positive results can occur if the urine is highly alkaline. [60] [62] Conventional test strips are not sensitive enough to reliably detect microalbuminuria, a condition in which urine albumin levels are slightly elevated, [64] although dipsticks specialized for this measurement exist. [62]
Automatic analysis of urine test strips using automated urine test strip analysers is a well-established practice in modern-day urinalysis. They can measure calcium , blood, glucose, bilirubin, urobilinogen, ketones, leukocytes, creatinine , microalbumin , pH, ascorbic acid and protein.
Reference ranges for urine tests are described below: Measurement Lower limit Upper limit Unit Urinary specific gravity: 1.003 [1] [2] 1.030 [1] [2] g/mL Urobilinogen:
Microalbuminuria: urinary albumin excretion in the range of 30–299 mg/24h; Macroalbuminuria: urinary albumin excretion ≥300 mg/24h; Urinary albumin excretion can also be measured by urinary albumin/creatinine ratio in a spot urine sample, which is as accurate but more convenient than a 24-hour urine collection. [29]
Urine analysis, urine cytology, complement activity, urine culture, and serological studies can help differentiate orthostatic albuminuria from other causes of proteinuria. Recumbent and upright urine protein to creatinine ratio is often used as a screening test. 24-hour split urine testing is often tested. [10]
The second-most common type of cast, granular casts can result either from the breakdown of cellular casts or the inclusion of aggregates of plasma proteins (e.g., albumin) or immunoglobulin light chains. Depending on the size of inclusions, they can be classified as fine or coarse, though the distinction has no diagnostic significance.