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A meta-analysis for associations between PFASs and human clinical biomarkers for liver injury, analyzing PFAS effects on liver biomarkers and histological data from rodent experimental studies, concluded that evidence exists that PFOA, perfluorohexanesulfonic acid (PFHxS), and perfluorononanoic acid (PFNA) caused hepatotoxicity in humans. [81]
2017 PFAS are on the Government of Canada's 2019 chart of substances prohibited by the Canadian Environmental Protection Act, 1999 (CEPA) and by the Prohibition of Certain Toxic Substances Regulations, 2012. These substances are under these regulations because they are "among the most harmful" and "have been declared toxic to the environment ...
The observed probable serious effects for human health and the environment are thyroid hormonal disturbances and reproductive toxicity seen in rodents, and effects on liver, kidney and haematological system in rats, hormonal disturbances and effects on reproduction in marine medaka fish and effects on expression of hormone receptors in tadpoles.
The rule sets limits for five individual PFAS: PFOA, PFOS, PFNA, PFHxS, and HFPO-DA (also known as “GenX Chemicals”), as well as a limit for mixtures of any two or more of four PFAS: PFNA ...
In humans, PFHxS binds to blood albumin, [8] and relatively little PFHxS is found in the liver compared to longer chain PFASs such as PFOS. [9] The half-life of PFHxS in adult blood serum is 5.3 years (4.7 years for women and 7.4 years for men). [10] The half-life of PFASs in human blood generally decreases with decreasing backbone (CF 2) length.
PFAS’s pervasiveness and the public's heightened awareness of the chemicals’ potential dangers have made companies litigation and regulation targets.
There is a growing body of research investigating the health effects of PFOS in humans and animals, including the reproductive, developmental, liver, kidney, thyroid, and immunological effects. [42] According to a 2002 report by the Environmental Directorate of the OECD , "PFOS is persistent, bioaccumulative, and toxic to mammalian species."
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