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The Purkinje layer of the cerebellum, which contains the cell bodies of the Purkinje cells and Bergmann glia, express a large number of unique genes. [9] Purkinje-specific gene markers were also proposed by comparing the transcriptome of Purkinje-deficient mice with that of wild-type mice. [10]
There are three layers to the cerebellar cortex; from outer to inner layer, these are the molecular, Purkinje, and granular layers. The function of the cerebellar cortex is essentially to modulate information flowing through the deep nuclei. The microcircuitry of the cerebellum is schematized in Figure 5.
The large, spherical cell bodies of Purkinje cells are packed into a narrow layer (one cell thick) of the cerebellar cortex, called the Purkinje layer. After emitting collaterals that affect nearby parts of the cortex, their axons travel into the deep cerebellar nuclei , where they make on the order of 1,000 contacts each with several types of ...
There are four paired deep cerebellar nuclei embedded in the white matter centre of the cerebellum. The nuclei are the fastigial , globose , emboliform , and dentate nuclei. In lower mammals the emboliform nucleus appears to be continuous with the globose nucleus, and these are known together as the interposed nucleus .
Purkinje fibers take up stain differently from the surrounding muscle cells because of having relatively fewer myofibrils than other cardiac cells. The presence of glycogen around the nucleus causes Purkinje fibers to appear, on a slide, lighter and larger than their neighbors, being arranged along the longitudinal direction (parallel to the ...
In the cerebellum, the multipolar basket cells have branching dendrites, which are dilated and knotty. Basket cells synapse on the cell bodies of Purkinje cells and make inhibitory synapses with Purkinje cells. Cerebellar basket cell axons fire inhibitory neurotransmitters such as GABA to Purkinje cell axons, and inhibits the Purkinje cell. [9]
Each climbing fiber will form synapses with 1-10 Purkinje cells. Early in development, Purkinje cells are innervated by multiple climbing fibers, but as the cerebellum matures, these inputs gradually become eliminated resulting in a single climbing fiber input per Purkinje cell.
Purkinje cells of flocculonodular lobe → juxtarestiform body of inferior cerebellar peduncle → vestibular nuclei (synapse/termination of cerebellovestibular fibers) → Medial and lateral vestibulospinal tracts (extrapyramidal upper motor neurons) → (synapse) lower motor neurons → skeletal muscle