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Methotrexate is given either orally or intramuscularly, followed by vaginal misoprostol 3–5 days later. [22] The methotrexate combination is available through 63 days. The WHO authorizes the methotrexate-misoprostol combination [ 42 ] but recommends the mifepristone combination because methotrexate may be teratogenic to the embryo in cases of ...
Misoprostol is used for the prevention of NSAID-induced gastric ulcers.It acts upon gastric parietal cells, inhibiting the secretion of gastric acid by G-protein coupled receptor-mediated inhibition of adenylate cyclase, which leads to decreased intracellular cyclic AMP levels and decreased proton pump activity at the apical surface of the parietal cell.
Prostaglandin E 1 (PGE 1) is a naturally occurring prostaglandin with various medical uses. Alprostadil and misoprostol are synthetic forms of prostaglandin E1 used as medications. Lubiprostone, a derivative of prostaglandin E1, is also used as a medication. [2] [3] Prostaglandin E 1 is a vasodilator.
Several doctors with a private practice offer online consultations and e-prescriptions for a fee. [71] Honduras: Central America: N/A: N/A: After having been available one for cases of rape, it became legal for universal access in March 2023. [72] [73] Hong Kong: Asia [74] Iceland: Europe (LNG only) [75] India: Asia <33% [76] Indonesia: Asia ...
An abortion is one of the most common surgical procedures in Trinidad and Tobago, and most occur during the first 12 weeks of pregnancy. [3]According to the World Health Organization (WHO), an unsafe abortion is "a procedure for terminating an unwanted pregnancy either by persons lacking the necessary skills or in an environment lacking the minimal medical standards or both". [3]
Misoprostol and other prostaglandin analogues protect the lining of the gastrointestinal tract from harmful stomach acid and are especially indicated for the elderly on continuous doses of NSAIDs. In the field of ophthalmology , drugs of this class are used to lower intraocular pressure (IOP) in people with glaucoma .
A single preovulatory 10-mg dose of mifepristone delays ovulation by three to four days and is as effective an emergency contraceptive as a single 1.5-mg dose of the progestin levonorgestrel. [55] In women, mifepristone at doses greater or equal to 1 mg/kg antagonizes the endometrial and myometrial effects of progesterone.
The American College of Rheumatology and a Canadian consensus report both recommend GI-protective agents such as misoprostol be combined with long term NSAID therapy and a review concluded that diclofenac/misoprostol is a cost effective treatment in patients requiring long term NSAID therapy who are at increased risk of developing gastropathy. [4]
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