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2. Alcohol withdrawal syndrome - Wikipedia

   en.wikipedia.org/wiki/Alcohol_withdrawal_syndrome

   Signs and symptoms of alcohol withdrawal occur primarily in the central nervous system. The severity of withdrawal can vary from mild symptoms such as insomnia, trembling, and anxiety to severe and life-threatening symptoms such as alcoholic hallucinosis, delirium tremens, and autonomic instability.

3. Post-acute-withdrawal syndrome - Wikipedia

   en.wikipedia.org/wiki/Post-acute-withdrawal_syndrome

   The protracted withdrawal syndrome from benzodiazepines, opioids, alcohol and other addictive substances can produce symptoms identical to generalized anxiety disorder as well as panic disorder. Due to the sometimes prolonged nature and severity of benzodiazepine, opioid and alcohol withdrawal, abrupt cessation is not advised. [13]

4. Impact of alcohol on aging - Wikipedia

   en.wikipedia.org/wiki/Impact_of_alcohol_on_aging

   Alcohol is a potent neurotoxin. [5] The National Institute on Alcohol Abuse and Alcoholism has found, "Alcoholism may accelerate normal aging or cause premature aging of the brain." [6] Another report by the same agency found, "Chronic alcohol consumption, as well as chronic glucocorticoid exposure, can result in premature and/or exaggerated ...

5. Delirium tremens - Wikipedia

   en.wikipedia.org/wiki/Delirium_tremens

   Delirium tremens is a component of alcohol withdrawal hypothesized to be the result of compensatory changes in response to chronic heavy alcohol use. Alcohol positively allosterically modulates the binding of GABA , enhancing its effect and resulting in inhibition of neurons projecting into the nucleus accumbens , as well as inhibiting NMDA ...

6. Kindling (sedative–hypnotic withdrawal) - Wikipedia

   en.wikipedia.org/wiki/Kindling_(sedative...

   Ethanol (alcohol) has a very similar mechanism of tolerance and withdrawal to benzodiazepines, involving the GABA A receptors, NMDA receptors and AMPA receptors, but the majority of research into kindling has primarily focused on alcohol. [6] An intensification of anxiety and other psychological symptoms of alcohol withdrawal also occurs. [10]

7. Alcohol-related dementia - Wikipedia

   en.wikipedia.org/wiki/Alcohol-related_dementia

   Alcohol can damage the brain directly as a neurotoxin, [5] or it can damage it indirectly by causing malnutrition, primarily a loss of thiamine (vitamin B1). [2] Alcohol use disorder is common in older persons, and alcohol-related dementia is under-diagnosed. [3]