Search results
Results from the WOW.Com Content Network
Natural killer cells, also known as NK cells, are a type of cytotoxic lymphocyte critical to the innate immune system. They are a kind of large granular lymphocytes [ 1 ] [ 2 ] (LGL), and belong to the rapidly expanding family of known innate lymphoid cells (ILC) and represent 5–20% of all circulating lymphocytes in humans. [ 3 ]
NK-tumor recognition protein is a protein that in humans is encoded by the NKTR gene. [5] [6] [7] This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its expression is regulated ...
This term describes cells with abnormally low levels of a cell-surface marker called MHC I (major histocompatibility complex) - a situation that can arise in viral infections of host cells. [10] They were named "natural killer" because of the initial notion that they do not require activation in order to kill cells that are "missing self".
Natural killer (NK) cells are a type of lymphocyte cell involved in the innate immune system's response to viral infection and tumor transformation of host cells. [20] [7] Like T cells, NK cells have many qualities characteristic of the adaptive immune system, including the production of “memory” cells that persist following encounter with antigens and the ability to create a secondary ...
Based on their structure there are three different groups of KARS. The first group of receptors is called Natural Cytotoxicity Receptors (NCR), which only includes activation receptors. The two other classes are: Natural Killer Group 2 , which includes activation and inhibition receptors, and some KIRs which do not have an inhibitor role. [7]
CD94/NKG2 is a family of C-type lectin receptors which are expressed predominantly on the surface of NK cells and a subset of CD8 + T-lymphocyte. [1] [2] These receptors stimulate or inhibit cytotoxic activity of NK cells, therefore they are divided into activating and inhibitory receptors according to their function. [3]
MICA rather functions as a stress-induced ligand (as a danger signal) for integral membrane protein receptor NKG2D ("natural-killer group 2, member D"). MICA is broadly recognized by NK cells, γδ T cells, and CD8 + αβ T cells which carry NKG2D receptor on their cell surface and which are activated via this interaction. [7]
Natural cytotoxicity triggering receptor 1 is a protein that in humans is encoded by the NCR1 gene. [ 5 ] [ 6 ] NCR1 has also been designated as CD335 ( cluster of differentiation , NKP46, NKp46, NK-p46, and LY94 .