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During regeneration, only cartilage cells can form new cartilage tissue, only muscle cells can form new muscle tissue, and so on. The dedifferentiated cells still retain their original specification. [12] To begin the physical formation of a new limb, regeneration occurs in a distal to proximal sequence. [17]
They are crucial for the repair of muscle, but have a very limited ability to replicate. Activated by stimuli such as injury or high mechanical load, satellite cells are required for muscle regeneration in adult organisms. [3] In addition, satellite cells have the capability to also differentiate into bone or fat. In this way, satellite cells ...
Transdifferentiation, also known as lineage reprogramming, [1] is the process in which one mature somatic cell is transformed into another mature somatic cell without undergoing an intermediate pluripotent state or progenitor cell type. [2]
Compensatory hyperplasia permits tissue and organ regeneration. It is common in epithelial cells of the epidermis and intestine, liver hepatocytes, bone marrow cells, and fibroblasts. It occurs to a lesser extent in bone, cartilage, and smooth muscle cells. Hormonal hyperplasia occurs mainly in organs that depend on estrogen. For example, the ...
Platelet-derived growth factor (PDGF) is one among numerous growth factors that regulate cell growth and division.In particular, PDGF plays a significant role in blood vessel formation, the growth of blood vessels from already-existing blood vessel tissue, mitogenesis, i.e. proliferation, of mesenchymal cells such as fibroblasts, osteoblasts, tenocytes, vascular smooth muscle cells and ...
Interstitial cells of Cajal (ICC) are interstitial cells found in the gastrointestinal tract.There are different types of ICC with different functions. ICC and another type of interstitial cell, known as platelet-derived growth factor receptor alpha (PDGFRα) cells, are electrically coupled to smooth muscle cells via gap junctions, that work together as an SIP functional syncytium. [2]
A single satellite cell can proliferate and become a larger amount of muscle cells. [28] With the understanding that myosatellite cells are the progenitor of most skeletal muscle cells, it was theorized that if these cells could be grown in a lab and placed on scaffolds to make fibers, the muscle cells could then be used for food production. [29]
Timing is important to wound healing. Critically, the timing of wound re-epithelialization can decide the outcome of the healing. [11] If the epithelization of tissue over a denuded area is slow, a scar will form over many weeks, or months; [12] [13] If the epithelization of a wounded area is fast, the healing will result in regeneration.