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Increased urination is a commonly reported side effect, particularly during the initial phase following treatment initiation; this is mostly transient and tends to reduce with sustained treatment. Common side effects for antimineralocorticoid medications include nausea and vomiting, stomach cramps and diarrhoea. [4]
Typical mineralocorticoid side-effects are hypertension (abnormally high blood pressure), steroid induced diabetes mellitus, psychosis, poor sleep, hypokalemia (low potassium levels in the blood), hypernatremia (high sodium levels in the blood) without causing peripheral edema, metabolic alkalosis and connective tissue weakness. [5]
The name mineralocorticoid derives from early observations that these hormones were involved in the retention of sodium, a mineral.The primary endogenous mineralocorticoid is aldosterone, although a number of other endogenous hormones (including progesterone [1] and deoxycorticosterone) have mineralocorticoid function.
Other serious side effects can include low immune-system function, cataracts, muscle weakness, and mood changes. [3] Whether use of fludrocortisone during pregnancy is safe for the fetus is unknown. [5] Fludrocortisone is mostly a mineralocorticoid, but it also has glucocorticoid effects. [3] Fludrocortisone was patented in 1953. [6]
Finerenone is a non-steroidal mineralocorticoid receptor antagonist (MRA). [7] It is taken orally (swallowed by mouth). Common side effects include hyperkalemia (high levels of potassium) (normal 3.5-5.5mg/dl), hypotension (low blood pressure), and hyponatremia (low levels of sodium). [8]
These side effects were reported in five percent or more of people in Ozempic trials. The most common side effects of Mounjaro include: Nausea. Vomiting. Stomach pain. Constipation. Diarrhea ...
Triamterene – increased renal side-effects; Aldosterone antagonists, also known as mineralocorticoid receptor antagonists: [7] Spironolactone – most widespread use, inexpensive; Eplerenone – more selective so reduced side-effects but more expensive and less potent
Side effects include irregular heartbeat, fatigue, high blood pressure, dry mouth, and eyes that are itchy, red, and/or swollen. Carbonic anhydrase inhibitors (Trusopt, Azopt): This is another ...