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Paracortical hyperplasia is the preferential stimulation of the T cell compartment. It is caused by an abnormal expansion of the interfollicular zones but is confined within the lymph node capsule. The population of the compartment is cytologically polymorphous. Paracortical hyperplasia may be accompanied by vascular proliferation.
A lymph node, or lymph gland, [1] is a kidney-shaped organ of the lymphatic system and the adaptive immune system. ... Histology of a normal lymphoid follicle, ...
Lymph node enlargement can occur for many reasons. First of all, the lymph nodes function to act as a filter for the reticuloendothelial system. They contain multi-layered sinus by exposing B and T cell lymphocytes and macrophages and are found within the blood. When the immune system recognizes foreign proteins in order to mount an attack, it ...
Germinal centers or germinal centres (GCs) are transiently formed structures within B cell zone (follicles) in secondary lymphoid organs – lymph nodes, ileal Peyer's patches, and the spleen [1] – where mature B cells are activated, proliferate, differentiate, and mutate their antibody genes (through somatic hypermutation aimed at achieving higher affinity) during a normal immune response ...
Follicular dendritic cells (FDC) are cells of the immune system found in primary and secondary lymph follicles (lymph nodes) of the B cell areas of the lymphoid tissue. [ 1 ] [ 2 ] [ 3 ] Unlike dendritic cells (DC), FDCs are not derived from the bone-marrow hematopoietic stem cell , but are of mesenchymal origin. [ 4 ]
A lymph node is an organized collection of lymphoid tissue, through which the lymph passes on its way back to the blood. Lymph nodes are located at intervals along the lymphatic system. Several afferent lymph vessels bring in lymph, which percolates through the substance of the lymph node, and is then drained out by an efferent lymph vessel.
Hemal nodes were first described by Gibbes in 1884. [3] Hemal nodes appear similar to lymph nodes in the structure of its lymphoid follicles and to the spleen in the structure in its lymphoid cords. [4] It is presumed to have the same function as the spleen. [5]
These B cells then leave the bone marrow and migrate via bloodstream and the lymph to peripheral lymphoid tissues, such as a spleen, lymph nodes, tonsils and mucosal tissues. Once in a secondary lymphoid organ the B cell can be introduced to an antigen that it is able to recognize. [citation needed]