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Triclocarban has been used as an antimicrobial and antifungal compound since the 1960s. [5] It was commonly found in personal care products as an antimicrobial in soaps, lotions, deodorants, toothpaste, and plastic. [6] As of 2005 about 80% of all antimicrobial bar soap sold in the United States contained triclocarban. [5]
Miconazole is a widely used topical antifungal medication for the treatment of many fungal infections, namely skin infections, nail infections and vaginal candidiasis. The drug is usually formulated in creams, powders and sprays. However, it is suggested that patients developing acute porphyrias should avoid using this drug.
The advisory panel first met on June 29, 1972, and the agency published its proposed rule on Sept 13, 1974. The initial rule applied to, "OTC products containing antimicrobial ingredients for topical human use, which includes soaps, surgical scrubs, skin washes, skin cleansers, first aid preparations and additional products defined by the panel."
They are used to disinfect the skin before injections, among other uses. Diguanides including chlorhexidine gluconate, a bacteriocidal antiseptic which (with an alcoholic solvent) is considered a safe and effective antiseptic for reducing the risk of infection after clean surgery, [11] including tourniquet-controlled upper limb surgery. [12]
Thiomersal's main use is as an antiseptic and antifungal agent, due to its oligodynamic effect. In multidose injectable drug delivery systems, it prevents serious adverse effects such as the Staphylococcus infection that, in one 1928 incident, killed 12 of 21 children vaccinated with a diphtheria vaccine that lacked a preservative. [ 18 ]
Ketoconazole has activity against many kinds of fungi that may cause human disease, such as Candida, Histoplasma, Coccidioides, and Blastomyces (although it is not active against Aspergillus), chromomycosis and paracoccidioidomycosis. [23] [13] First made in 1977, [20] ketoconazole was the first orally-active azole antifungal medication. [23]
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