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Melanotan II acts as a non-selective agonist of the melanocortin receptors MC 1, MC 3, MC 4, and MC 5. [4]Melanotan II produces melanogenesis by activation of the MC 1 receptor, whereas its clinically documented sexual effects are thought to be related to its ability to activate the MC 4 receptor (though the MC 3 is thought to also possibly be involved).
In 1982 Kelly sold his interest in the company to Fisher, who renamed it Fisher Mountain Bikes. Also in 1979, Kelly began contributing articles to bicycle publications on the new and growing sport of mountain biking. [citation needed] In 1980 Kelly and Denise Caramagno started the first mountain bike magazine, The Fat Tire Flyer. [6]
A unidirectional Class II bicycle lane has a minimum clear width of 2.44 m (8.0 ft) or briefly narrowed to 1.50 m (4.9 ft) in narrow road sections. Class IIa bicycle lanes are distinguished by physical separation using bollards, curbs, plant boxes, concrete barriers, or a median strip with elevation changes, similar to cycle tracks. Class IIb ...
This page lists notable bicycle brands and manufacturing companies past and present. For bicycle parts, see List of bicycle part manufacturing companies.. Many bicycle brands do not manufacture their own product, but rather import and re-brand bikes manufactured by others (e.g., Nishiki), sometimes designing the bike, specifying the equipment, and providing quality control.
Rocky Mountain Bicycles has won Mountain Bike Magazine's 'Mountain Bike of the Year' award three times - for the Hammer Race in 1996, the Element Race in 2000, and the Slayer in 2002. Rocky Mountain has also seen one of its sponsored riders, Marie-Hélène Prémont , win a silver Olympic medal in 2004.
GT Avalanche 1.0. GT Bicycles, Inc. is an American company that designs and manufactures BMX, mountain, and road bicycles. GT is a division of the Dutch conglomerate Pon Holdings, which also markets Cannondale, Schwinn, Mongoose, IronHorse, DYNO, and RoadMaster bicycle brands; all manufactured in Asia.
The first Merlin frame was a mountain bike frame custom-built for the defending National Mountain Bike Champion Joe Murray. [2] In the following year, the company began a strong relationship with frame designer Tom Kellogg, who helped them produce the world's first 3-2.5 titanium alloy road bicycle frame. [ 2 ]
His bike, the Gary Fisher RS-1, was released in 1992. Its rear suspension adapted the A-arm suspension design from sports car racing, and was the first four-bar linkage in mountain biking. [ 8 ] In 1992, Howie Cohen, who had previously imported Nishiki , Azuki and Kuwahara bicycles, assisted Gary Fisher with his brand, [ 9 ] 18 months later ...
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