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This gating is reduced in schizophrenia patients relative to normal subjects. [2] Social withdrawal One of the negative symptoms of schizophrenia is social withdrawal, this has been modelled by socially isolating animals. [2] Locomotor traits Some locomotor changes, including stereotypy, are used to test the validity of animal models. Locomotor ...
Schizophrenia is a mental disorder [17] [7] characterized variously by hallucinations (typically, hearing voices), delusions, disorganized thinking and behavior, [10] and flat or inappropriate affect. [7] Symptoms develop gradually and typically begin during young adulthood and are never resolved.
The causes of schizophrenia that underlie the development of schizophrenia, a psychiatric disorder, are complex and not clearly understood.A number of hypotheses including the dopamine hypothesis, and the glutamate hypothesis have been put forward in an attempt to explain the link between altered brain function and the symptoms and development of schizophrenia.
Scores are often given separately for the positive items, negative items, and general psychopathology. In their original publication on the PANSS scale, Stanley Kay and colleagues tested the scale on 101 adult patients (20-68 years-old) with schizophrenia [4] and the mean scores were, Positive scale = 18.20; Negative scale = 21.01
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Schizophreniform disorder is a type of mental illness that is characterized by psychosis and closely related to schizophrenia.Both schizophrenia and schizophreniform disorder, as defined by the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR), have the same symptoms and essential features except for two differences: the level of functional impairment and the duration of symptoms.
Instead of viewing schizophrenia as a by-product of brain evolution, one model presents schizophrenia to be one extreme of a sexually selected fitness indicator. [26] This model hypothesizes schizophrenia to be a side effect in sexual selection for certain traits. Sexual selection concerns the mating choices of humans and other animals.
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