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This is referred to as air inhibition and is a diffusion-controlled reaction with rates typically in the order of 10 7 –10 9 mol −1 s −1, [3] the resulting peroxy radicals (ROO•) are less reactive towards polymerisation. However air stabilisation is not suitable for monomers with which it can form explosive peroxides, such as vinyl ...
A specialist may request a quantitative factor Xa assay in a situation of overdose. [2] Andexanet alfa, a specific antidote to reverse the anticoagulant activity of direct Xa inhibitors in the event of major bleeding, was approved by the FDA in 2018. [9] It is also available in the UK. [10]
Alpha 2-antiplasmin (or α 2-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for inactivating plasmin. [5] Plasmin is an important enzyme that participates in fibrinolysis and degradation of various other proteins. This protein is encoded by the SERPINF2 gene. [6] Fibrinolysis (simplified).
A trypsin inhibitor (TI) is a protein and a type of serine protease inhibitor that reduces the biological activity of trypsin by controlling the activation and catalytic reactions of proteins. [1] Trypsin is an enzyme involved in the breakdown of many different proteins , primarily as part of digestion in humans and other animals such as ...
Dapagliflozin is an example of an SGLT-2 inhibitor, it is a competitive, highly selective inhibitor of SGLT. It acts via selective and potent inhibition of SGLT-2, and its activity is based on each patient's underlying blood sugar control and kidney function. The results are decreased kidney reabsorption of glucose, glucosuria effect increases ...
Due to the minus sign, higher values of pIC 50 indicate exponentially more potent inhibitors. pIC 50 is usually given in terms of molar concentration (mol/L, or M), thus requiring IC 50 in units of M. [2] The IC 50 terminology is also used for some behavioral measures in vivo, such as the two bottle fluid consumption test.
3-Amino-1,2,4-triazole (3-AT) is a heterocyclic organic compound that consists of 1,2,4-triazole with an amino group as a substituent. 3-AT is a competitive inhibitor of the product of the HIS3 gene, imidazoleglycerol-phosphate dehydratase. [3] [4] Imidazoleglycerol-phosphate dehydratase is an enzyme catalyzing the sixth step of histidine ...
These phosphinate MMP inhibitors contain phenyl segments that are thought to be responsible for the selectivity to MMP-13. The phosphinic group of those inhibitors (R 1 R 2 (O)OH) binds as a zinc ligand. R 1 and R 2 substituents affect the inhibition potency. [7] Phosphinate inhibitors have been developed that showed high selectivity for MMP-11.