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In contrast, acitretin's half-life is approximately 2 days. However, because acitretin can be reverse metabolised into etretinate which has an extremely long half-life, women must avoid becoming pregnant for at least three years [10] after discontinuing acitretin. Therefore, acitretin is generally not recommended for women of child-bearing age ...
Acitretin is highly teratogenic and noted for the possibility of severe birth defects. It was initially suggested as a replacement for Etretinate. [28] It should not be used by pregnant women or women planning to get pregnant within 3 years following the use of acitretin.
Etretinate has been replaced by acitretin, the free acid (without the ethyl ester). While acitretin is less lipophilic and has a half-life of only 50 hours, it is partly metabolized to etretinate in the body, [2] so that it is still a long-acting teratogen and pregnancy is prohibited for two years after therapy. [3]
Skin tags have also been associated with pregnancy and certain chronic conditions, including: insulin resistance, pre-diabetes, diabetes and metabolic syndrome, adds Shastry. Lastly, because there ...
[33] [34] The use of acitretin, alitretinoin and isotretinoin should be prohibited in women of childbearing age unless they take measures to prevent pregnancy. [35] The use of topical retinoids should also be excluded during pregnancy and in women planning pregnancy. [citation needed]
A study confirmed that side effects like pancreatitis and kidney damage are possible while taking GLP-1s like Ozempic. Here's what a doctor wants you to know.
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