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Estradiol (E2) is a medication and naturally occurring steroid hormone. [11] [12] [13] It is an estrogen and is used mainly in menopausal hormone therapy and to treat low sex hormone levels in women.
Transdermal estradiol gel produces an estradiol to estrone ratio of about 1:1. [10] [12] Transdermal estradiol gel can be used as a form of high-dose estrogen in transgender women. [224] However, the doses needed require application to a large surface of skin that amounts to the combined area of both legs for proper absorption. [224]
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