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Prurigo nodularis (PN), also known as nodular prurigo, is a skin disorder characterized by pruritic , nodular lesions, which commonly appear on the trunk, arms and legs. [1] Patients often present with multiple excoriated nodules caused by chronic scratching.
Prurigo is a reactive skin condition distinguished by numerous, isolated itchy papules. [1] The word "prurigo" comes from the Latin word pruire, which meaning itching. Ferdinand von Hebra coined the term "prurigo" in Vienna in 1850 to describe papules and nodules that had severe pruritus . [ 2 ]
Dryness, heat, cold, stress, and showering all exacerbate pruritus. Patients with this condition frequently have skin devoid of noticeable lesions. But in addition to xerosis, skin lesions like excoriation, crusts, impetigo, and prurigo nodularis may also develop as a result of repeated scratching. [4]
Nara Smith is opening up about her health challenges.. The 23-year-old social media star got candid in a new Instagram post that detailed her journey with eczema and eventually Lupus after she ...
Chronic scratching of lesions can cause thickening or lichenification of the skin or prurigo nodularis (generalized nodules that are severely itchy). [33] Another factor in the barrier failure and immunological dysregulation in people with atopic dermatitis may be due to decreases in tight junction protein Claudin-1.
Increased NGF is also found in atopic dermatitis, a hereditary and non-contagious skin disease with chronic inflammation. [28] NGF is known to up-regulate neuropeptides, especially substance P . Substance P has been found to have an important role in inducing pain; however, there is no confirmation that substance P directly causes acute ...
Lupus is a chronic disease that can cause inflammation and pain in any part of the body. The disease impacts about 1.5 million Americans, but women are nine times more likely to develop lupus than ...
The skin weighs an average of four kilograms, covers an area of two square metres, and is made of three distinct layers: the epidermis, dermis, and subcutaneous tissue. [1] The two main types of human skin are: glabrous skin, the hairless skin on the palms and soles (also referred to as the "palmoplantar" surfaces), and hair-bearing skin. [3]