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Losartan, valsartan, candesartan, irbesartan, telmisartan and olmesartan all contain a biphenyl-methyl group. Losartan is partly metabolized to its 5-carboxylic acid metabolite EXP 3174, which is a more potent AT 1 receptor antagonist than its parent compound [17] and has been a model for the continuing development of several other ARBs. [1]
Telmisartan, sold under the brand name Micardis among others, is a medication used to treat high blood pressure and heart failure. [ 3 ] [ 6 ] It is a reasonable initial treatment for high blood pressure. [ 6 ]
Olmesartan, sold under the brand name Benicar among others, is a medication used to treat high blood pressure (hypertension). [ 1 ] [ 2 ] It is taken orally (swallowed by mouth). [ 2 ] Versions are available as the combination olmesartan/hydrochlorothiazide and olmesartan/amlodipine . [ 2 ]
People can get exhausted taking multiple pills during the course of the day, but we know with hypertension, many people’s blood pressure is not controlled with just one drug, so it does ...
However, AT 1 affinity vs AT 2 is not a meaningful indicator of blood pressure response. [38] Losartan – 1000-fold [citation needed] Telmisartan – 3000-fold [citation needed] Irbesartan – 8500-fold [citation needed] Candesartan – greater than 10000-fold [citation needed] Olmesartan – 12500-fold [citation needed]
Azilsartan, candesartan, eprosartan, irbesartan, olmesartan, telmisartan, valsartan; ARBs are generally well-tolerated, in which they are less likely to cause cough or angioedema compared to ACEI. Common side effects include hypotension, renal insufficiency, and hyperkalemia. [7]
Amlodipine/olmesartan, sold under the brand name Azor, among others is a fixed-dose combination medication used to treat high blood pressure. [5] It contains amlodipine , as the besilate, a dihydropyridine calcium channel blocker , and olmesartan medoxomil , an angiotensin II receptor blocker .
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