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Vitiligo (/ ˌ v ɪ t ɪ ˈ l aɪ ɡ oʊ /, vi-ti-leye-goh) is a chronic autoimmune disorder that causes patches of skin to lose pigment or color. [1] The cause of vitiligo is unknown, but it may be related to immune system changes, genetic factors, stress, or sun exposure. [5] [6] Treatment options include topical medications, light therapy ...
Cell damage (also known as cell injury) is a variety of changes of stress that a cell suffers due to external as well as internal environmental changes. Amongst other causes, this can be due to physical, chemical, infectious, biological, nutritional or immunological factors.
In immunology, autoimmunity is the system of immune responses of an organism against its own healthy cells, tissues and other normal body constituents. [1] [2] Any disease resulting from this type of immune response is termed an "autoimmune disease".
Some genetic conditions that result in a "leucistic" appearance include piebaldism, Waardenburg syndrome, vitiligo, Chédiak–Higashi syndrome, flavism, isabellinism, xanthochromism, axanthism, amelanism, and melanophilin mutations. Pale patches of skin, feathers, or fur (often referred to as "depigmentation") can also result from injury.
In addition to genetic factors, poliosis can develop due to various inflammatory, autoimmune, or neoplastic conditions, or as a side effect of medication. Vitiligo: This autoimmune disorder leads to the destruction of melanocytes, resulting in depigmented skin patches. Poliosis is present in half of patients with segmental vitiligo. [5]
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Vitiligo patients are at risk to contract melanoma, and an annual cancer check-up is recommended. [28] Jackson also covered his skin disorder with clothing wearing long sleeves and long pants. In the music video for " Remember the Time ", all dancers and actors except for Jackson are lightly dressed following the example set by ancient ...
Oxidative stress mechanisms in tissue injury. Free radical toxicity induced by xenobiotics and the subsequent detoxification by cellular enzymes (termination).. Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. [1]