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Anti-tetanus immunoglobulin, also known as tetanus immune globulin (TIG) and tetanus antitoxin, is a medication made up of antibodies against the tetanus toxin. [1] It is used to prevent tetanus in those who have a wound that is at high risk, have not been fully vaccinated with tetanus toxoid , or have HIV/AIDS .
Tetanus antiserum was developed in 1890, with its protective effects lasting a few weeks. [9] [10] The tetanus toxoid vaccine was developed in 1924, and came into common use for soldiers in World War II. [2] [11] Its use resulted in a 95% decrease in the rate of tetanus. [2] It is on the World Health Organization's List of Essential Medicines. [12]
In drug development and medical device development [1] the Investigator's Brochure (IB) is a comprehensive document summarizing the body of information about an investigational product ("IP" or "study drug") obtained during a drug trial. The IB is a document of critical importance throughout the drug development process and is updated with new ...
The test detects antibodies against foreign red blood cells. In this case, serum is extracted from a blood sample taken from the patient. The serum is incubated with foreign red blood cells of known antigenicity. Finally, anti-human globulin is added. If agglutination occurs, the indirect Coombs test is positive. [2]
Immunoglobulin therapy is the use of a mixture of antibodies (normal human immunoglobulin) to treat several health conditions. [13] [14] These conditions include primary immunodeficiency, immune thrombocytopenic purpura, chronic inflammatory demyelinating polyneuropathy, Kawasaki disease, certain cases of HIV/AIDS and measles, Guillain–Barré syndrome, and certain other infections when a ...
Only 43.6% of adults (older than 18) have received a TDaP shot in the last 10 years. [20] The CDC aims to increase vaccination rate among 2-year-olds from 80.4% to 90.0% [ 21 ] The World Health Organization (WHO) estimates that 89% of people globally have received at least one dose of DTP vaccine and 84% have received three doses of the vaccine ...
Tetanus toxoid can be given in case of a suspected exposure to tetanus. In such cases, it can be given with or without tetanus immunoglobulin (also called tetanus antibodies or tetanus antitoxin [10]). It can be given as intravenous therapy or by intramuscular injection. [citation needed]
Tetanus immunoglobulin (TIG), [1] also called tetanus antibodies or tetanus antitoxin. [46] It can be given as intravenous therapy or by intramuscular injection. Antibiotic therapy to reduce toxin production. Metronidazole intravenous (IV) is a preferred treatment. [48] Benzodiazepines can be used to control muscle spasms.