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Pomalidomide, sold under the brand names Pomalyst and Imnovid, [7] [8] is an anti-cancer medication used for the treatment of multiple myeloma and AIDS-related Kaposi sarcoma. [ 7 ] Pomalidomide was approved for medical use in the United States in February 2013, [ 10 ] and in the European Union in August 2013. [ 8 ]
Feet of a baby born to a mother who had taken thalidomide while pregnant. In the late 1950s and early 1960s, the use of thalidomide in 46 countries was prescribed to women who were pregnant or who subsequently became pregnant, and consequently resulted in the "biggest anthropogenic medical disaster ever," with more than 10,000 children born with a range of severe deformities, such as ...
Haloperidol, a known cause of NMS: Specialty: Critical care medicine, neurology, psychiatry: Symptoms: High fever, confusion, rigid muscles, variable blood pressure, sweating [1] Complications: Rhabdomyolysis, high blood potassium, kidney failure, seizures [1] [2] Usual onset: Within a few weeks or days [3] Causes: Antipsychotic medication [1 ...
In the late 1950s and early 1960s, more than 10,000 children in 46 countries were born with deformities, such as phocomelia, as a consequence of thalidomide use. [75] The severity and location of the deformities depended on how many days into the pregnancy the mother was before beginning treatment, with the time-sensitive window occurring ...
Phocomelia is a congenital condition that involves malformations of human arms and legs which result in a flipper-like appendage. [1] [2] A prominent cause of phocomelia is the mother being prescribed the use of the drug thalidomide during pregnancy; however, the causes of most cases are to be determined.
A major rockslide prompted two highways to be shut down in Colorado over the weekend and witnesses captured the frightening moment on video. Highways 96 and 165 from Wetmore to Westcliffe in ...
An early segment homes in on Andy and Rachel — two Gata players who have kinda-sorta liked each other from the beginning, but never got the chance t Survivor Recap: Mass Confusion Causes a Live ...
The thalidomide molecule is a synthetic derivative of glutamic acid and consists of a glutarimide ring and a phthaloyl ring (Figure 5). [15] [16] Its IUPAC name is 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione and it has one chiral center [15] After thalidomide's selective inhibition of TNF-α had been reported, a renewed effort was put in thalidomide's clinical development.